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Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity

Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity.

This is a paper I’ve linked before, and for good reason. It’s refreshing to see what the fields of nutrition and obesity research are actually doing, as contrasted with the caricatures and kooky pseudoscience passed around the internet (i.e. “starvation mode”). It’s also a neat illustration of how biology and environment interact to regulate body weight, which is a factor often left out of the deterministic causal-chains-of-biomolecules thought process.

In a larger scope, it also illustrates why we should be very careful of saying that any given thing “causes” or “explains” any particular outcome in a tightly-knit network such as regulation of body weight. Neat and tidy stories about molecules appeal to human brains but don’t always reflect the reality in any meaningful way.