So I found a testimonial that looked pretty good in a book by a former NASA scientist who has nothing to do with bodybuilding or PL or fitness; he said good things about a resveratrol supp called
Longevinex. I took a look through the site, and contacted the guy who owns it, named Bill Sardi, who turns out to be a complete asshole. Strangely enough, this made me want to try the supp more so I bought a couple months' worth. Will give an opinion about it later this year.
In the meantime, any of you scientific types have anything to say about Longevinex, or resveratrol (supps or otherwise) in general? Longevinex has something called "trans resveratrol"; I talked to a guy who talked to Cy Willson, who said that resveratrol is basically resveratrol, and there is no difference. Sardi, of course, says otherwise. I don't know enough to really follow the arguments back and forth...
Something makes me want to say it has problems with being available when taken orally. I could be remembering wrong though.
You mean in supplement form? (Otherwise all Res. is taken orally...)
Cy Wilson, is that the old drug guy from Tmag?
I dont know about the chemistry, but the last thing I saw about Resveratrol was in regards to being a caloric restriction mimetic. Stuff has been published in bugs (the usual first step for CR research) and some stuff in fat mice/rats. They relate it back to hte concept of hormesis, or xenohormesis and the plant under stress creates stress related molecules, which when consumed, create a tiny stress to our bodies, which creates a positive adaptataion.
Glaxo Smith Kline brought out one of hte big resveratrol suppliers the other year, Sirtris Pharma.
Yeah, Cy Willson is the (young) old drug guy from T-Mag. One of my good IRL friends here has become good friends with him via the Net. I didn't find anything particularly objectionable about Cy's work over at T-Mag, but I don't know that he has any particular knowledge about resveratrol. (Probably not on his radar yet, given his age, hahaha.)
Bill Sardi has been saying that trans-resveratrol does exactly what you said - mimics calorie restriction. One point that he made is that real calorie restriction activates sirtuin response differently in different tissues (it's not a blanket, same-everywhere effect), and that his Longevinex (and French red wine as well) does the same thing, as opposed to the sirtuin stuff that's being manufactured by the new companies. It also supposedly activates more genes than just plain resveratrol, including the Sirtuin-1 DNA repair gene.
Here's the "
quick fact sheet" if you're interested. I don't know enough about it to make any sort of real judgment, although his arguments sound better than the usual bunk.
From what I've read in the financial news, Sirtis Pharma was basically created to be brought out by a big drug company. I don't know that they have any real expertise in resveratrol or anything else, but the guy who started it up has had something like 25 other start-ups that he's successfully sold. So
that's his expertise, not biochem or anything else.
Unless he has quality clinical evidence for his product being better, then he is likely to be doing nothing more than a marketing job. At least, thats what i get from the 'fact sheet'